Result: More than 100 studies on 2.45 GHz radiation were analyzed, most of which found changes compared to the control groups at levels below the safety guidelines of the International Commission on Non-Ionizing Radiation Protection (ICNIRP) (issued as exposure limits of the 26th Federal Pollution Control Ordinance (BImSchV) in Germany). The available studies document damage to the reproductive system, impacts on the EEG and brain functions, as well as effects on the heart, liver, thyroid, gene expression, cell cycle, cell membranes, bacteria, and plants. As a mechanism of action, many studies identify oxidative stress. Adverse effects on learning, memory, attention, and behavior are the result of cytotoxic effects.
SafeSleeve's report is right up front about showing that they do not test or certify the Safe Sleeve case, rather they are simply testing the material they put into the case in a completely artificial environment, in a laboratory setting, using a signal generator and a power amplifier. Safe Sleeve includes photos showing how the measurements are taken. But that may not be how anyone will ever use their phone.
W. Kim Johnson, a retired physicist and past president of the New Mexico Academy of Science, reviewed the Aires web site for Discovery News and described the material as gibberish, saying that the authors "of the technical description of the ‘Aires' device reads like a random selection of technical terminology. The working description for this device is made up of jargon that, in the end, really says nothing."
Anything you can do to keep the phone away from your head will help. (Even cell phone manufacturers warn consumers about this. See the previous post Cell Phone Manual Warnings for examples of warnings from Samsung, Apple and more.) If you hold the phone 2 inches away, the signal is about one-fourth the original strength. At four inches away, it’s about 1/16th as strong. Even better is a hands-free kit with a wireless air tube nearest the earpiece. (A regular wired headset can act as an antenna and make matters worse.)
The aim of this study was to determine the structural changes in the frontal cortex, brainstem and cerebellum in the male rat brain due to electromagnetic wave exposure (900, 1800, 2450 MHz, 1h/day for 2 months). While the histopathological changes in the frontal cortex and brainstem were normal in the control group, there were severe degenerative changes, shrunken cytoplasm and extensively dark pyknotic nuclei in the EMR groups. Biochemical analysis demonstrated that the Total Antioxidative Capacity level was significantly decreased in the EMR groups and also Total Oxidative Capacity and Oxidative Stress Index levels were significantly increased in the frontal cortex, brainstem and cerebellum. Researchers concluded that EMR causes structural changes in the frontal cortex, brainstem and cerebellum and impairs the oxidative stress and inflammatory cytokine system. This deterioration can cause to disease including loss of these areas function and cancer development.
Remarkably, cell phones had been allowed onto the US consumer market a decade earlier without any government safety testing. Now, some customers and industry workers were being diagnosed with cancer. In January 1993, David Reynard sued the NEC America Company, claiming that his wife’s NEC phone caused her lethal brain tumor. After Reynard appeared on national TV, the story went viral. A congressional subcommittee announced an investigation; investors began dumping their cell-phone stocks; and Wheeler and the CTIA swung into action.2
Cell phones emit radiofrequency (RF) radiation, and RF radiation has been shown to damage DNA and cause cancer in laboratory animals. A peer-reviewed Jan. 2012 study in the Journal of Neuro-Oncology concluded that RF radiation "may damage DNA and change gene expression in brain cells" in mice.  An Aug. 2009 meta-study found that RF radiation "can alter the genetic material of exposed cells."  A 2004 European Union-funded study also found that cell phone radiation can damage genes.  On May 26, 2016, the US National Toxicology Program (NTP) released the first results of its study on cell phone radiation, finding an increased incidence of malignant tumors of the brain (gliomas) and heart tumors (schwannomas) in rats exposed to RF radiation.  The NTP researchers also found DNA damage in the rats exposed to the highest levels of RF radiation.  On Nov. 1, 2018, the NTP released its final peer-reviewed report, concluding that there is "clear evidence of carcinogenic activity” in male rats exposed to RF radiation. 
Drivers that talk on cell phones while they drive may be at risk for accidents. A handful of states have made hand-held cell phone use illegal while operating a motor vehicle. Plug into a headset or hands-free device and then you’re safe, or so seems the message. But a growing stable of studies suggests that drivers engaged in complex conversations, hands-free or otherwise, are a leading roadway danger.
The RF signals from cell phones, as well as Bluetooth and WiFi, are considered nonionizing forms of radiation. That means unlike ionizing radiation—from, say, ultraviolet light from the sun, medical tests such as CT scans or X-rays, or nuclear explosions—they don’t carry enough energy to directly break or alter your DNA, which is one way cancer can occur.
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Nevertheless, a group of scientists got together in the mid-2000s, calling themselves the BioInitiative Working Group. This group, which largely consisted of wireless radiation researchers, has written a harsh reply as feedback to the reports claiming that posed no health risks. The reply lists a wide range of health effects scientists at the European Commission have unfortunately either ignored or dismissed.